{"id":10,"date":"2024-02-15T07:50:15","date_gmt":"2024-02-14T22:50:15","guid":{"rendered":"http:\/\/ohnishi.mc-tsukuba.com\/?page_id=10"},"modified":"2024-02-28T12:09:31","modified_gmt":"2024-02-28T03:09:31","slug":"research","status":"publish","type":"page","link":"https:\/\/biosignal.dept.med.gunma-u.ac.jp\/?page_id=10","title":{"rendered":"\u7814\u7a76\u7d39\u4ecb"},"content":{"rendered":"\n<ol>\n<li><a href=\"#title01\">\u7814\u7a76\u5185\u5bb9<\/a>\n<ol>\n<li><a href=\"#title01-1\">\u86cb\u767d\u8cea\u30c1\u30ed\u30b7\u30f3\u30ea\u30f3\u9178\u5316\u3092\u4ecb\u3057\u305f\u7d30\u80de\u6a5f\u80fd\u306e\u5236\u5fa1\u6a5f\u69cb<\/a><\/li>\n<li><a href=\"#title01-2\">\u65b0\u3057\u3044\u7d30\u80de\u9593\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u6a5f\u69cbCD47-SHPS-1\u7cfb\u306e\u751f\u7406\u6a5f\u80fd\u3068\u305d\u306e\u81e8\u5e8a\u5fdc\u7528<\/a><\/li>\n<\/ol>\n<\/li>\n<li><a href=\"#title02\">\u7814\u7a76\u5ba4\u3067\u4fee\u5f97\u3067\u304d\u308b\u6280\u8853\u4e00\u89a7<\/a><\/li>\n<li><a href=\"\/r-01\/\">\u6700\u8fd1\u306e\u7dcf\u8aac<\/a><br \/><a href=\"?page_id=86\">\u300c\u65b0\u898f\u7d30\u80de\u9593\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30b7\u30b9\u30c6\u30e0CD47-SHPS-1\u7cfb\u306e\u6a5f\u80fd\u300d\uff08\u7d30\u80de\u5de5\u5b66\u3000vol.23, No5, 2004\uff09<\/a><\/li>\n<\/ol>\n<h4><a name=\"title01\"><\/a>\uff11\u3000\u7814\u7a76\u5185\u5bb9<\/h4>\n<h5>\u7814\u7a76\u5ba4\u306e\u76ee\u6a19<\/h5>\n<p>\u79c1\u5171\u306f\u3001\u751f\u547d\u79d1\u5b66\u306e\u591a\u304f\u306e\u9818\u57df\u3067\u57fa\u672c\u3068\u306a\u308b\u65b0\u305f\u306a\u7d30\u80de\u6a5f\u80fd\u306e\u5236\u5fa1\u6a5f\u69cb\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u304d\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e \u3059\u3002\u305d\u306e\u305f\u3081\u306b\u306f\u3001\u79c1\u5171\u72ec\u81ea\u306b\u3001\u8208\u5473\u3042\u308b\u751f\u547d\u73fe\u8c61\u306b\u95a2\u4e0e\u3059\u308b\u300c\u6a5f\u80fd\u5206\u5b50\u300d\u3092\u540c\u5b9a\u3057\u3001\u3053\u308c\u306b\u3064\u304d\u751f\u5316\u5b66\u7684\u3001\u5206\u5b50\u751f\u7269\u5b66\u7684\u3001\u7d30\u80de\u751f\u7269\u5b66\u7684\u3001\u7d30\u80de\u5de5\u5b66\u7684\u306a\u5e45\u5e83\u3044 \u7814\u7a76\u624b\u6cd5\u3092\u7528\u3044\u591a\u89d2\u7684\u306b\u305d\u306e\u6a5f\u80fd\u89e3\u6790\u3092\u884c\u3044\u307e\u3059\u3002\u305d\u3057\u3066\u3001\u6700\u7d42\u7684\u306b\u306f\u3001\u304c\u3093\u3084\u795e\u7d4c\u75be\u60a3\u3001\u4ee3\u8b1d\u30fb\u5185\u5206\u6ccc\u75be\u60a3\u3001\u52d5\u8108\u786c\u5316\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u69d8\u3005\u306a\u75be\u60a3\u306e\u8a3a\u65ad\u3084\u6cbb\u7642 \u306e\u4e0a\u3067\u3001\u79c1\u5171\u306e\u7814\u7a76\u6210\u679c\u304c\u9084\u5143\u3055\u308c\u308b\u3088\u3046\u306a\u7814\u7a76\u3092\u76ee\u6307\u3057\u3066\u3044\u304d\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<br \/>\u79c1\u5171\u306f\u3001\u7814\u7a76\u3092\u3059\u3059\u3081\u308b\u4e0a\u3067\u3001\u6b21\u306e\uff13\u3064\u306e\u5927\u304d\u306a\u76ee\u6a19\u3092\u3042\u3052\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><span style=\"color: #003366;\">I)\u3000\u65b0\u305f\u306a\u7d30\u80de\u5185\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\u6a5f\u69cb\u306e\u767a\u898b<\/span><br \/><span style=\"color: #003366;\">? II)\u3000\u65b0\u305f\u306a\u751f\u7406\u6d3b\u6027\u7269\u8cea\u306e\u767a\u898b\u3068\u305d\u306e\u4f5c\u7528\u6a5f\u69cb\u306e\u89e3\u660e<\/span><br \/><span style=\"color: #003366;\">?III)\u3000I)\uff0cII) \u3092\u57fa\u790e\u3068\u3057\u305f\u81e8\u5e8a\u5fdc\u7528<\/span><\/p>\n<p>\u3053\u308c\u3089\uff13\u3064\u306e\u5927\u76ee\u6a19\u3092\u76ee\u6307\u3057\u3064\u3064\u3001\u79c1\u5171\u306f\u3001\u5f53\u9762\u306f\u4ee5\u4e0b\u306e\u5177\u4f53\u7684\u306a\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306b\u3064\u304d\u7814\u7a76\u3092\u5c55\u958b\u3057\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n<h5><a name=\"title01-1\"><\/a>\uff11\uff09\u3000\u86cb\u767d\u8cea\u30c1\u30ed\u30b7\u30f3\u30ea\u30f3\u9178\u5316\u3092\u4ecb\u3057\u305f\u7d30\u80de\u6a5f\u80fd\u306e\u5236\u5fa1\u6a5f\u69cb<\/h5>\n<p>\u86cb\u767d\u8cea\u306e\u30c1\u30ed\u30b7\u30f3\u30ea\u30f3\u9178\u5316\u306f\u3001\u5b9f\u306b\u69d8\u3005\u306a\u7d30\u80de\u6a5f\u80fd\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u4e2d\u3067\u3082\u6700\u3082\u4ee3\u8868\u7684\u306a\u3082\u306e\u3068\u3057\u3066\u7d30\u80de\u306e\u5897\u6b96\u3068\u5206\u5316\u304c\u3042\u308a\u307e\u3059\uff08\u56f3\uff11\uff09\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" title=\"\uff11\uff09\u3000\u86cb\u767d\u8cea\u30c1\u30ed\u30b7\u30f3\u30ea\u30f3\u9178\u5316\u3092\u4ecb\u3057\u305f\u7d30\u80de\u6a5f\u80fd\u306e\u5236\u5fa1\u6a5f\u69cb\" src=\"\/wp-content\/uploads\/work1.gif\" alt=\"\uff11\uff09\u3000\u86cb\u767d\u8cea\u30c1\u30ed\u30b7\u30f3\u30ea\u30f3\u9178\u5316\u3092\u4ecb\u3057\u305f\u7d30\u80de\u6a5f\u80fd\u306e\u5236\u5fa1\u6a5f\u69cb\" width=\"500\" height=\"256\" \/><\/p>\n<p>\u591a\u304f\u306e\u7d30\u80de\u5897\u6b96\u56e0\u5b50\u3084\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u53d7\u5bb9\u4f53\u81ea\u8eab\u304c\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\u6d3b\u6027\u3092\u3082\u3063\u3066\u304a\u308a\u3001\u3053\u308c\u304c\u53d7\u5bb9\u4f53\u81ea\u8eab\u3084\u7d30\u80de\u5185\u306e\u6a19 \u7684\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30c1\u30ed\u30b7\u30f3\u30ea\u30f3\u9178\u5316\u3057\u3066\u6700\u7d42\u7684\u306b\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u4ecb\u3057\u3066\u7d30\u80de\u306e\u5897\u6b96\u3068\u5206\u5316\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u307e\u305f\u305d\u306e\u7570\u5e38\u306f\u3001\u7d30\u80de\u306e\u304c\u3093\u5316\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002\u307e\u305f\u3001 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title=\"\u86cb\u767d\u8cea\u30c1\u30ed\u30b7\u30f3\u30ea\u30f3\u9178\u5316\u306e\u30d0\u30e9\u30f3\u30b9\u5236\u5fa1\u6a5f\u69cb\" src=\"\/wp-content\/uploads\/work2.gif\" alt=\"\u86cb\u767d\u8cea\u30c1\u30ed\u30b7\u30f3\u30ea\u30f3\u9178\u5316\u306e\u30d0\u30e9\u30f3\u30b9\u5236\u5fa1\u6a5f\u69cb\" width=\"562\" height=\"353\" \/><\/p>\n<p>\u307e\u305f\u3001\u3053\u306e\u30d0\u30e9\u30f3\u30b9\u306e\u7834\u7dbb\u304c\u3001\u304c\u3093\u3084\u7cd6\u5c3f\u75c5\u3001\u514d\u75ab\u7570\u5e38\u306a\u3069\u69d8\u3005\u306a\u75be\u60a3\u306e\u539f\u56e0\u3068\u306a\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u30c1\u30ed\u30b7\u30f3\u30ea\u30f3\u9178\u5316\u306e\u5236\u5fa1\u6a5f\u69cb\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u306f\u3001\u751f\u7406\u7684\u306a\u7d30\u80de\u6a5f\u80fd\u306e\u89e3\u660e\u3068\u3044\u3046\u9762\u304b\u3089\u3060\u3051\u3067\u306a\u304f\u3001\u533b\u5b66\u4e0a\u3082\u5927\u5909\u91cd\u8981\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<p>\u79c1\u5171\u306f\u3001\u3053\u308c\u307e\u3067\u4e00\u8cab\u3057\u3066src-\u30db\u30e2\u30ed\u30b8\u30fc\uff12\u9818\u57df\uff08SH2\u30c9\u30e1\u30a4\u30f3\uff09\u3092\u6709\u3057\u3066\u3044\u308b\u30c1\u30ed\u30b7\u30f3\u30db\u30b9\u30d5\u30a1\u30bf\u30fc\u30bc\u3001SHP-2\u306e\u7d30\u80de\u6a5f\u80fd\u306b\u304a\u3051\u308b\u5f79\u5272\u306b\u3064\u304d\u7814\u7a76\u3092\u7d99\u7d9a\u3057\u3066\u3044\u307e\u3059\uff08\u56f3\uff13\uff09\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" title=\"SHP-2\u306f\u5897\u6b96\u56e0\u5b50\u306b\u3088\u308bRas\u6d3b\u6027\u5316\u306b\u5fc5\u8981\u3067\u3042\u308b\" src=\"\/wp-content\/uploads\/work3.gif\" alt=\"SHP-2\u306f\u5897\u6b96\u56e0\u5b50\u306b\u3088\u308bRas\u6d3b\u6027\u5316\u306b\u5fc5\u8981\u3067\u3042\u308b\" width=\"500\" height=\"339\" \/><\/p>\n<p>\u305d\u306e\u7d50\u679c\u3001SHP-2\u304c\u3001\u5897\u6b96\u56e0\u5b50\u523a\u6fc0\u306b\u3088\u308bRas\u4f4e\u5206\u5b50\u91cfG\u86cb\u767d\u8cea\u306e\u6d3b\u6027\u5316\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057 \u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3001\u6700\u8fd1\u3001\u79c1\u5171\u306f\u3001\u6975\u6027\u3092\u6709\u3059\u308b\u4e0a\u76ae\u7cfb\u7d30\u80de\u306e\u30e2\u30c7\u30eb\u3067\u3042\u308bMDCK\u7d30\u80de\u306b\u304a\u3044\u3066\u3001SHP-2\u304c\u3001GDP\/GTP\u4ea4\u63db\u4fc3\u9032\u86cb\u767d\u8cea\u3067\u3042\u308bVav2 \u3092\u4ecb\u3057\u3066\u3001\u4f4e\u5206\u5b50\u91cfG\u86cb\u767d\u8ceaRho\u306e\u6d3b\u6027\u5316\u3092\u5236\u5fa1\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u7d30\u80de\u57fa\u8cea\u9593\u63a5\u7740\u3092\u8abf\u7bc0\u3057\u3001\u809d\u7d30\u80de\u5897\u6b96\u56e0\u5b50\uff08HGF\uff09\u306b\u3088\u308a\u523a\u6fc0\u3055\u308c\u308b\u7d30\u80de\u904a\u8d70\u3092\u30dd\u30b8\u30c6\u30a4\u30d6 \u306b\u5236\u5fa1\u3059\u308b\u3053\u3068\u3092\u898b\u3044\u51fa\u3057\u3066\u3044\u307e\u3059\uff08\u56f3\uff14\uff09\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" title=\"SHP-2-Vav2-Rho\u7cfb\u3068HGF\u306b\u3088\u308b\u7d30\u80de\u904b\u52d5\" src=\"\/wp-content\/uploads\/work4.gif\" alt=\"SHP-2-Vav2-Rho\u7cfb\u3068HGF\u306b\u3088\u308b\u7d30\u80de\u904b\u52d5\" width=\"588\" height=\"331\" \/><\/p>\n<p>\u3055\u3089\u306b\u3001SHP-2\u306e\u8131\u30ea\u30f3\u9178\u5316\u57fa\u8cea\u86cb\u767d\u8cea\u3068\u3057\u3066\u3001\u30a4\u30e0\u30ce\u30b0\u30ed\u30d6\u30ea\u30f3\u30b9\u30fc\u30d1\u30fc\u30d5\u30a1\u30df\u30ea\u30fc\u306b\u5c5e\u3059\u308bSHPS-1\u3068 HGF\u53d7\u5bb9\u4f53\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\uff08c-Met\uff09\u306e\u30c1\u30ed\u30b7\u30f3\u30ea\u30f3\u9178\u5316\u57fa\u8cea\u3067\u3042\u308bGab-1\u3092\u898b\u51fa\u3057\u3066\u3044\u307e\u3059\u3002SHPS-1\u306f\u3001\u63a5\u7740\u56e0\u5b50\u30a4\u30f3\u30c6\u30b0\u30ea\u30f3\u3092\u4ecb\u3057\u305f\u7d30 \u80de\u57fa\u8cea\u9593\u63a5\u7740\u306b\u3088\u308a\u3001\u307e\u305fGab-1\u306f\u3001\u63a5\u7740\u56e0\u5b50\u30ab\u30c9\u30d8\u30ea\u30f3\u3092\u4ecb\u3057\u305f\u7d30\u80de\u9593\u63a5\u7740\u306b\u3088\u3063\u3066\u30c1\u30ed\u30b7\u30f3\u30ea\u30f3\u9178\u5316\u3092\u53d7\u3051\u3001\u305d\u308c\u305e\u308c\u304cSHP-2\u306b\u3088\u308a\u305d\u306e\u30c1\u30ed\u30b7\u30f3 \u30ea\u30f3\u9178\u5316\u30ec\u30d9\u30eb\u304c\u5236\u5fa1\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306b\u3001\u79c1\u5171\u306f\u3001SHP-2\u304c\u3001\u5897\u6b96\u56e0\u5b50\u3068\u7d30\u80de\u63a5\u7740\u306e\u4e21\u65b9\u306e\u4e0b\u6d41\u306b\u4f4d\u7f6e\u3057\u3001\uff12\u3064\u7570\u306a\u308b\u4f4e\u5206\u5b50\u91cfG\u86cb\u767d\u8ceaRas\u3068 Rho\u3092\u5236\u5fa1\u3059\u308b\u591a\u6a5f\u80fd\u306a\u30b7\u30b0\u30ca\u30eb\u5206\u5b50\u3067\u3042\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u307e\u3059\uff08\u56f3\uff14\uff09\u3002<\/p>\n<p>\u79c1\u5171\u306f\u4eca\u5f8c\u3055\u3089\u306b\u3001\u7d30\u80de\u306e\u5897\u6b96\u30fb\u63a5\u7740\u30fb\u904b\u52d5\u306e\u5236\u5fa1\u6a5f\u69cb\u306b\u304a\u3051\u308b\u86cb\u767d\u8cea\u30c1\u30ed\u30b7\u30f3\u30ea\u30f3\u9178\u5316\u306e\u5f79\u5272\u3092\u3055\u3089\u306b \u660e\u3089\u304b\u306b\u3059\u308b\u76ee\u7684\u3067\u3001SHP-2\u306e\u4f5c\u7528\u6a5f\u69cb\u306b\u7126\u70b9\u3092\u7d5e\u308a\u3001SHP-2\u306b\u3088\u308b\u4f4e\u5206\u5b50\u91cfG\u86cb\u767d\u8cea\u306e\u6d3b\u6027\u5236\u5fa1\u6a5f\u69cb\u3001SHPS-1\u907a\u4f1d\u5b50\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u7d30\u80de\u306e \u89e3\u6790\u3001\u30a4\u30f3\u30c6\u30b0\u30ea\u30f3\u7cfb\u3068SHPS-1\/SHP-2\u7cfb\u306e\u76f8\u4e92\u4f5c\u7528\u3001\u30ab\u30c9\u30d8\u30ea\u30f3\u7cfb\u3068Gab-1\/SHP-2\u7cfb\u306e\u76f8\u4e92\u4f5c\u7528\u306a\u3069\u306b\u3064\u3044\u3066\u7dcf\u5408\u7684\u306b\u89e3\u6790\u3092\u9032\u3081\u3066\u3044\u304f \u4e88\u5b9a\u3067\u3059\u3002\u307e\u305f\u5c06\u6765\u7684\u306b\u306f\u3001\u3053\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7cfb\u304c\u3001\u514d\u75ab\u6a5f\u80fd\u3084\u8a18\u61b6\u30fb\u5b66\u7fd2\u7b49\u306e\u795e\u7d4c\u6a5f\u80fd\u3092\u59cb\u3081\u3068\u3059\u308b\u9ad8\u6b21\u751f\u547d\u73fe\u8c61\u3001\u3055\u3089\u306b\u306f\u8001\u5316\u306e\u5206\u5b50\u6a5f\u69cb\u306b\u3069\u306e\u3088\u3046\u306b\u95a2\u4e0e \u3057\u3066\u3044\u308b\u304b\u306b\u3064\u3044\u3066\u3082\u7814\u7a76\u3092\u5c55\u958b\u3057\u3066\u3044\u304d\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n<p style=\"float: right;\"><a href=\"#top\">\u25b2TOP<\/a><\/p>\n<h5><a name=\"title01-2\"><\/a>\uff12\uff09\u3000\u65b0\u3057\u3044\u7d30\u80de\u9593\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u6a5f\u69cbCD47-SHPS-1\u7cfb\u306e\u751f\u7406\u6a5f\u80fd\u3068\u305d\u306e\u81e8\u5e8a\u5fdc\u7528<\/h5>\n<p>\u591a\u7d30\u80de\u751f\u7269\u306e\u500b\u4f53\u3092\u5f62\u6210\u3059\u308b\u69d8\u3005\u306a\u7a2e\u985e\u306e\u7d30\u80de\u306f\u4e92\u3044\u306b\u30b7\u30b0\u30ca\u30eb\u3092\u53d7\u3051\u6e21\u3057\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u5354\u8abf\u7684\u306b\u4f5c\u7528\u3057\u3042\u3044\u3001\u305d\u306e\u7d50\u679c\u591a\u69d8 \u306a\u751f\u4f53\u6a5f\u80fd\u304c\u767a\u73fe\u3057\u307e\u3059\u3002\u3053\u306e\u7d30\u80de\u9593\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30b7\u30b9\u30c6\u30e0\u306e\uff11\u3064\u306e\u57fa\u672c\u578b\u306f\u3001\u30b7\u30b0\u30ca\u30eb\u3092\u4f1d\u3048\u308b\u5074\u306e\u7d30\u80de\u4e0a\u306b\u56fa\u5b9a\u3055\u308c\u305f\u819c\u7d50\u5408\u578b\u306e\u30ea\u30ac\u30f3\u30c9\u5206\u5b50\u304c\u3001\u6a19\u7684\u7d30 \u80de\u4e0a\u306e\u30ec\u30bb\u30d7\u30bf\u30fc\u5206\u5b50\u306b\u76f4\u63a5\u4f1a\u5408\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u30e1\u30c3\u30bb\u30fc\u30b8\u3092\u4f1d\u3048\u308b\u6a5f\u69cb\u3067\u3059\u3002\u79c1\u5171\u306f\u3001\u3053\u306e\u7d30\u80de\u9593\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30b7\u30b9\u30c6\u30e0\u306b\u76f8\u5f53\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u308bCD47- SHPS-1\u7cfb\u3092\u65b0\u305f\u306b\u898b\u3044\u51fa\u3057\u3066\u3044\u307e\u3059\u3002CD47-SHPS-1\u7cfb\u306f\u3001\uff11\u56de\u819c\u8cab\u901a\u578b\u306e\u30ec\u30bb\u30d7\u30bf\u30fc\u578b\u5206\u5b50\u3067\u3042\u308bSHPS-1\uff08SH2- containing Protein Tyrosine Phosphatase Substrate-1\uff09\u3068\u3001\u305d\u306e\u7d30\u80de\u5916\u9818\u57df\u306e\u751f\u7406\u7684\u306a\u30ea\u30ac\u30f3\u30c9\u3067\u3042\u308b\u3084\u306f\u308a\u819c\u8cab\u901a\u578b\u5206\u5b50\u3067\u3042\u308bCD47\u306b\u3088\u308a\u69cb\u6210\u3055\u308c\u307e\u3059\u3002SHPS-1\u306f\u3001\u79c1\u5171\u304c\u30c1\u30ed \u30b7\u30f3\u30db\u30b9\u30d5\u30a1\u30bf\u30fc\u30bcSHP-2\u306e\u7d50\u5408\u86cb\u767d\u8cea\u3067\u3042\u308a\u307e\u305f\u8131\u30ea\u30f3\u9178\u5316\u57fa\u8cea\u3068\u3057\u3066\u540c\u5b9a\u3057\u305f\u7d30\u80de\u819c\u8cab\u901a\u578b\u306e\u86cb\u767d\u8cea\u3067\u3059\uff08\u56f3\uff15\uff09\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" title=\"CD47\u3068SHPS-1\u306b\u3088\u308b\u7d30\u80de\u9593\u76f8\u4e92\u4f5c\u7528\u30b7\u30b0\u30ca\u30eb\" src=\"\/wp-content\/uploads\/work5.gif\" alt=\"CD47\u3068SHPS-1\u306b\u3088\u308b\u7d30\u80de\u9593\u76f8\u4e92\u4f5c\u7528\u30b7\u30b0\u30ca\u30eb\" width=\"415\" height=\"344\" \/><\/p>\n<p>SHPS-1\u306f\u3001\u305d\u306e\u7d30\u80de\u5916\u30c9\u30e1\u30a4\u30f3\u306b\uff13\u500b\u306e\u514d\u75ab\u30b0\u30ed\u30d6\u30ea\u30f3\u69d8\u69cb\u9020\u3092\u3082\u3061\u307e\u3059\u3002\u4e00\u65b9\u3001\u305d\u306e\u7d30\u80de\u5185\u30c9\u30e1\u30a4\u30f3\u306b\u306f\u3001\u5897\u6b96\u56e0\u5b50\u3084 \u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3001\u7d30\u80de\u63a5\u7740\u523a\u6fc0\u306a\u3069\u306b\u3088\u308a\u30c1\u30ed\u30b7\u30f3\u30ea\u30f3\u9178\u5316\u3092\u53d7\u3051\u308b\u30e2\u30c1\u30fc\u30d5\u3092\u3082\u3061\u3001\u3053\u308c\u306bSH2\u30c9\u30e1\u30a4\u30f3\u3092\u3082\u3064\u7d30\u80de\u8cea\u578b\u30c1\u30ed\u30b7\u30f3\u30db\u30b9\u30d5\u30a1\u30bf\u30fc\u30bcSHP-2\u3042 \u308b\u3044\u306fSHP-1\u304c\u7d50\u5408\u3057\u3001\u3053\u308c\u3089\u306e\u30db\u30b9\u30d5\u30a1\u30bf\u30fc\u30bc\u304c\u6d3b\u6027\u5316\u3055\u308c\u307e\u3059\u3002\u5f93\u3063\u3066\u3001SHPS-1\u306e\u4e0b\u6d41\u30b7\u30b0\u30ca\u30eb\u306b\u306f\u3053\u308c\u3089\u306e\u30c1\u30ed\u30b7\u30f3\u30db\u30b9\u30d5\u30a1\u30bf\u30fc\u30bc\u304c\u95a2\u4e0e\u3059\u308b \u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3001CD47\u306f\u3001\u7d44\u7e54\u666e\u904d\u7684\u306b\u767a\u73fe\u3059\u308b\uff15\u56de\u7d30\u80de\u819c\u8cab\u901a\u578b\u306e\u86cb\u767d\u8cea\u3067\u3059\u3002\u305d\u306e\u7d30\u80de\u5916\u9818\u57df\u306b\u306f\uff11\u500b\u306e\u514d\u75ab\u30b0\u30ed\u30d6\u30ea\u30f3\u69d8\u69cb\u9020\u3092\u3082\u3061\u3001\u3053\u308c\u304c SHPS-1\u306e\u7d30\u80de\u5916\u30c9\u30e1\u30a4\u30f3\u3068\u4f1a\u5408\u3059\u308b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002CD47\u306e\u4e0b\u6d41\u30b7\u30b0\u30ca\u30eb\u306b\u3064\u3044\u3066\u306f\u3001\u672a\u3060\u5341\u5206\u660e\u3089\u304b\u3067\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<p>\u79c1\u5171\u306f\u3001\u3059\u3067\u306bCD47-SHPS-1\u7cfb\u304c\u666e\u904d\u7684\u306a\u7d30\u80de\u904b\u52d5\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u3088\u308b\u8caa\u98df\u6a5f\u80fd\u3001\u795e\u7d4c\u30b7\u30ca\u30d7\u30b9\u6a5f\u80fd\u306a\u3069\u306e\u5236\u5fa1\u306b\u304a\u3044\u3066\u3001\u4e3b\u306b\u8ca0\u306e\u5236\u5fa1\u3092\u884c\u3063\u3066\u3044\u308b\u91cd\u8981\u306a\u7d30\u80de\u9593\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u6a5f\u69cb\u3067\u3042\u308b\u3053\u3068\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u307e\u3059\u3002\u3059\u306a\u308f\u3061\u3001<\/p>\n<p>\uff11\uff09\u904b\u52d5\u3057\u3066\u3044\u308b\u7d30\u80de\u4e0a\u306eSHPS-1\u304c\u5225\u306e\u7d30\u80de\u4e0a\u306b\u767a\u73fe\u3059\u308bCD47\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u7d30\u80de\u904b\u52d5\u3092\u8ca0\u306b\u8abf\u7bc0\u3059\u308b\u3053\u3068\u3001 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