{"id":38,"date":"2024-02-15T16:05:07","date_gmt":"2024-02-15T07:05:07","guid":{"rendered":"https:\/\/ohnishi.mc-tsukuba.com\/?page_id=38"},"modified":"2025-01-09T11:59:24","modified_gmt":"2025-01-09T02:59:24","slug":"publications-en","status":"publish","type":"page","link":"https:\/\/biosignal.dept.med.gunma-u.ac.jp\/?page_id=38","title":{"rendered":"Publications"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">2025<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Moriya A, Inoue I, Saitow F, Keitoku M, Suzuki N, Oike E, Urano E, Matsumoto E, Suzuki H, Aoki Y, Ohnishi H.<br><strong>Q241R mutation of Braf causes neurological abnormalities in a mouse model of cardio-facio-cutaneous syndrome, independent of developmental malformations<\/strong><br>Hum Mol Genet, 2025, ddae196,&nbsp;<a href=\"https:\/\/doi.org\/10.1093\/hmg\/ddae196\">https:\/\/doi.org\/10.1093\/hmg\/ddae196&nbsp;<\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39774818\/\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n<\/ul>\n\n\n\n<p><a href=\"#top\">\u25b2TOP<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2023<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Komori S, Saito Y, Nishimura T, Respatika D, Endoh H, Yoshida H, Sugihara R, Iida-Norita R, Afroj T, Takai T, Oduori OS, Nitta E, Kotani T, Murata Y, Kaneko Y, Nitta R, Ohnishi H, Matozaki T.<br><strong>CD47 promotes peripheral T cell survival by preventing dendritic cell-mediated T cell necroptosis.<\/strong><br>Proc Natl Acad Sci USA 120 (33): e2304943120, 2023&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37549290\/\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n<\/ul>\n\n\n\n<p><a href=\"#top\">\u25b2TOP<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2022<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Sakamoto M, Murata Y, Tanaka D, Kakuchi Y, Okamoto T, Hazama D, Saito Y, Kotani T, Ohnishi H, Miyasaka M, Fujisawa M, Matozaki T.&nbsp;<br><strong>Anticancer efficiency of monotherapy with antibodies to SIRP\u03b1\/SIRP\u03b21 mediated by induction of antitumorigenic macrophages.&nbsp;<\/strong><br>Proc Natl Acad Sci USA 119 (1): e2109923118, 2022&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34949714\/\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n<\/ul>\n\n\n\n<p><a href=\"#top\">\u25b2TOP<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2021<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Jingu D, Iino M, Kawasaki J, Urano E, Kusakari S, Hayashi Y, Matozaki T, Ohnishi H.&nbsp;<br><strong>Protein tyrosine phosphatase Shp2 positively regulates cold stress-induced tyrosine phosphorylation of SIRP\u03b1 in neurons.&nbsp;<\/strong><br>Biochem Biophys Res Commun 569: 72-78, 2021&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34237430\/\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n<\/ul>\n\n\n\n<p><a href=\"#top\">\u25b2TOP<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2020<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Watanabe M,&nbsp;Kaneko Y,&nbsp;Ohishi Y,&nbsp;Kinoshita M,&nbsp;Sakairi T,&nbsp;Ikeuchi H,&nbsp;Maeshima A,&nbsp;Saito Y,&nbsp;Ohnishi H,&nbsp;Nojima Y,&nbsp;Matozaki T,&nbsp;Hiromura K.&nbsp;<br><strong>Importance of methodology in the evaluation of renal mononuclear phagocytes and analysis of a model of experimental nephritis with Shp1 conditional knockout mice.&nbsp;<\/strong><br>Biochem Biophys Rep 22: 100741, 2020&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32154390\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Nishimura T, Saito Y, Washio K, Komori S, Respatika D, Kotani T, Murata Y, Ohnishi H, Mizobuchi S, Matozaki T.&nbsp;<br><strong>SIRP\u03b1 on CD11c+ cells induces Th17 cell differentiation and subsequent inflammation in the CNS in experimental autoimmune encephalomyelitis<\/strong><strong>.<br><\/strong>Eur J Immunol 50(10): 1560-1570, 2020&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32438469\/\">[PubMed]<\/a><\/li>\n<\/ul>\n\n\n\n<p><a href=\"#top\">\u25b2TOP<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2019<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Sato-Hashimoto M, Nozu T, Toriba R, Horikoshi A, Akaike M, Kawamoto K, Hirose A, Hayashi Y, Nagai H, Shimizu W, Saiki A, Ishikawa T, Elhanbly R, Kotani T, Murata Y, Saito Y, Naruse M, Shibasaki K, Oldenborg P-A, Jung S, Matozaki T, Fukazawa Y, Ohnishi H.&nbsp;<br><strong>Microglial SIRP\u03b1 regulates the emergence of CD11c+ microglia and demyelination damage in white matter.&nbsp;<\/strong><br>eLife 8: e42025, 2019&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30910011\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Alkebsi L,&nbsp;Ohnishi H,&nbsp;Nakajima-Shimada J,&nbsp;Onizuka Y, Ideno Y,&nbsp;Sato Y,&nbsp;Hayashi K.&nbsp;<br><strong>Validation of the accuracy of self-reported ABO blood types in the Japan Nurses\u2019 Health Study.&nbsp;<\/strong><br>Asian Pac J Cancer Prev 20 (3): 789-793, 2019&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30909687\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n<\/ul>\n\n\n\n<p><a href=\"#top\">\u25b2TOP<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2018<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Alkebsi&nbsp;L,&nbsp;Ideno Y,&nbsp;Lee JS,&nbsp;Suzuki S,&nbsp;Nakajima-Shimada J,&nbsp;Ohnishi H,&nbsp;Sato Y,&nbsp;Hayashi&nbsp;K.&nbsp;<br><strong>Gastroduodenal ulcers and ABO blood group: the Japan Nurses&#8217; Health Study (JNHS).&nbsp;<\/strong><br>J Epidemiol 28(1):34-40, 2018&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29093357\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n<\/ul>\n\n\n\n<p><a href=\"#top\">\u25b2TOP<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2017<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Saito Y, Respatika D, Komori S, Washio K, Nishimura T, Kotani T, Murata Y, Okazawa H, Ohnishi H, Kaneko Y, Yui K, Yasutomo K, Nishigori C, Nojima Y, Matozaki T.&nbsp;<br><strong>SIRP\u03b1+&nbsp;dendritic cells regulate homeostasis of fibroblastic reticular cells via TNF receptor ligands in the adult spleen.&nbsp;<\/strong><br>Proc Natl Acad Sci USA 114(47):E10151-E10160, 2017&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29109283\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Yanagita T, Murata Y, Tanaka D, Motegi S, Arai E, Daniwijaya EW, Hazama D, Washio K, Saito Y, Kotani T, Ohnishi H, Oldenborg P-A, Garcia NV, Miyasaka M, Ishikawa O, Kanai Y, Komori T., Matozaki T.&nbsp;<br><strong>Anti-SIRP\u03b1 antibodies as a potential new tool for cancer immunotherapy.&nbsp;<\/strong><br>JCI Insight 2 (1): e89140, 2017&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28097229\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n<\/ul>\n\n\n\n<p><a href=\"#top\">\u25b2TOP<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2016<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Sakakura K, Takahashi H, Kaira K, Toyoda M, Murata T, Ohnishi H, Oyama T, Chikamatsu K.&nbsp;<br><strong>Relationship between tumor-associated macrophage subsets and CD47 expression in squamous cell carcinoma of the head and neck in the tumor microenvironment.&nbsp;<\/strong><br>Lab Invest 96 (9): 994-1003, 2016&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27322955\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n<\/ul>\n\n\n\n<p><a href=\"#top\">\u25b2TOP<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2015<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Moriya M, Inoue S, Miyagawa-Tomita S, Nakashima Y, Oba D, Niihori T, Hashi M, Ohnishi H, Kure S, Matsubara Y, Aoki Y.&nbsp;<br><strong>Adult mice expressing a Braf Q241R mutation on an ICR\/CD-1 background exhibit a cardio-facio-cutaneous syndrome phenotype.&nbsp;<\/strong><br>Hum Mol Genet 24 (25): 7349-7360, 2015&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26472072\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Murata Y, Kotani T, Supriatna Y, Kitamura Y, Imada S, Kawahara K, Nishio M, Daniwijaya EW, Sadakata H, Kusakari S, Mori M, Kanazawa Y, Saito Y, Okawa K, Takeda-Morishita M, Okazawa H, Ohnishi H, Azuma T, Suzuki A, Matozaki T.&nbsp;<br><strong>Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium&nbsp;<\/strong><br>Proc Natl Acad Sci USA 112 (31): E4264-4271, 2015&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26195794\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Kusakari S, Saitow F, Ago Y, Shibasaki K, Sato-Hashimoto M, Matsuzaki Y, Kotani T, Murata Y, Hirai H, Matsuda T, Suzuki H, Matozaki T, Ohnishi H.&nbsp;<br><strong>Shp2 in forebrain neurons regulates synaptic plasticity, locomotion, and memory formation in mice&nbsp;<\/strong><br>Mol Cell Biol 35 (9): 1557-1572, 2015&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25713104\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Motegi S, Yokoyama Y, Ogino S, Yamada K, Uchiyama A, Takeuchi Y, Ohnishi H, Ishikawa O.&nbsp;<br><strong>Pathogenesis of multiple lentigines in LEOPARD syndrome with PTPN11 gene mutation&nbsp;<\/strong><br>Acta Derm Venereol 95 (8): 978-984, 2015&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25917897\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Li XJ, Goodwin CB, Nabinger SC, Richine BM, Yang Z, Hanenberg H, Ohnishi H, Matozaki T, Feng GS, and Chan RJ.&nbsp;<br><strong>Protein tyrosine phosphatase, Shp2, positively regulates macrophage oxidative burst&nbsp;<\/strong><br>J Biol Chem 290 (7): 3894-3909, 2015&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25538234\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Washio K, Kotani T, Saito Y, Respatika D, Murata Y, Kaneko Y, Okazawa H, Ohnishi H, Fukunaga A, Nishigori C, Matozaki T.&nbsp;<br><strong>Dendritic cell SIRP\u03b1 regulates homeostasis of dendritic cells in lymphoid organs&nbsp;<\/strong><br>Genes Cells 20 (6): 451-463, 2015&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25818708\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n<\/ul>\n\n\n\n<p><a href=\"#top\">\u25b2TOP<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2014<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Yamashita H, Kotani T, Park JH, Murata Y, Okazawa H, Ohnishi H, Ku Y, Matozaki T.&nbsp;<br><strong>Role of the protein tyrosine phosphatase Shp2 in homeostasis of the intestinal epithelium&nbsp;<\/strong><br>PLoS One 9(3): e92904. 2014&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24675817\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Murata Y, Kotani T, Ohnishi H, Matozaki T.&nbsp;<br><strong>The CD47-SIRP\u03b1 signaling system: its physiological roles and therapeutic application<\/strong><br>J Biochem 155(6), 335-344, 2014&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24627525\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Koshimizu H, Takao K, Matozaki T, Ohnishi H, Miyakawa T.&nbsp;<br><strong>Comprehensive behavioral analysis of Cluster of Differentiation 47 knockout mice<\/strong><br>PLoS ONE 9(2): e89584. 2014&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24586890\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Murata Y, Saito Y, Kaneko T, Kotani T, Kaneko Y, Ohnishi H, Matozaki T.&nbsp;<br><strong>Autoimmune animal models in the analysis of the CD47-SIRP\u03b1 signaling pathway<\/strong><br>Methods 65, 254-259, 2014&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24091004\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Mantilidewi KI, Murata Y, Mori M, Otsubo C, Kotani T, Kusakari S, Ohnishi H, Matozaki T.&nbsp;<br><strong>Shear stress-induced redistribution of Vascular Endothelial-Protein Tyrosine Phosphatase (VE-PTP) in endothelial cells and its role in cell elongation<\/strong><br>J Biol Chem 289(19), 6451-6461, 2014&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24451369\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n<\/ul>\n\n\n\n<p><a href=\"#top\">\u25b2TOP<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2013<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Zen K, Guo Y, Bian Z, Lv Z, Zhu D, Ohnishi H, Matozaki T, Liu Y.<br><strong>Inflammation-induced proteolytic processing of the SIRP\u03b1 cytoplasmic ITIM in neutrophils propagates a proinflammatory state<\/strong><br>Nat. Commun. 4, 2436, 2013 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24026300\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Takahashi S, Tomioka M, Hiromura K, Sakairi T, Hamatani H, Watanabe M, Ikeuchi H, Kaneko Y, Maeshima A, Aoki T, Ohnishi H, Matozaki T, Nojima Y.<br><strong>SIRP\u03b1 signaling regulates podocyte structure and function<\/strong><br>Am J Physiol Renal Physiol 305(6), F861-870, 2013 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23842779\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n<\/ul>\n\n\n\n<p><a href=\"#top\">\u25b2TOP<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2012<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Hayashi Y, Kusakari S, Sato-Hashimoto M, Urano E, Shigeno M, Sekijima T, Kotani T, Murata Y, Murakami H, Matozaki T, Ohnishi H.<br><strong>Hypothermia-dependent and -independent effects of forced swim on the phosphorylation states of signaling molecules in mouse hippocampus<\/strong><br>Biochem Biophys Res Commun 428, 475-481, 2012 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23122813\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Maruyama T, Kusakari S, Sato-Hashimoto M, Hayashi Y, Kotani T, Murata Y, Okazawa H, Oldenborg P-A, Kishi S, Matozaki T, Ohnishi H.<br><strong>Hypothermia-induced tyrosine phosphorylation of SIRP\u03b1 in the brain<\/strong><br>J Neurochem 121, 891-902, 2012&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22468987\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Kaneko T, Saito Y, Kotani T, Okazawa H, Iwamura H, Sato-Hashimoto M, Kanazawa Y, Takahashi S, Hiromura K, Kusakari S, Kaneko Y, Murata Y, Ohnishi H, Nojima Y, Takagishi K, Matozaki T.<br><strong>Dendritic cell-specific ablation of the protein tyrosine phosphatase Shp1 promotes Th1 cell differentiation and induces autoimmunity<\/strong><br>J Immunol 188, 5397-5407, 2012&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22539788\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Nakakura T, Mogi C, Tobo M, Tomura H, Sato K, Kobayashi M, Ohnishi H, Tanaka S, Wayama M, Sugiyama T, Kitamura T, Harada A, Okajima F.<br><strong>Deficiency of proton-sensing ovarian cancer G protein-coupled receptor 1 attenuates glucose-stimulated insulin secretion<\/strong><br>Endocrinology 153, 4171-4180,&nbsp;2012 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22733973\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Wang L, Lu Y, Deng S, Zhang Y, Yang L, Guan Y, Matozaki T, Ohnishi H, Jiang H, Li H.<br><strong>SHPS-1 deficiency induces robust neuroprotection against experimental stroke by attenuating oxidative stress<\/strong><br>J Neurochem 122, 834-843, 2012&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22671569\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n<\/ul>\n\n\n\n<p><a href=\"#top\">\u25b2TOP<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2011<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Ohnishi H, Murata Y, Okazawa H, Matozaki T.<br><strong>Src family kinases: modulators of neurotransmitter receptor function and behavior<\/strong><br>Trends Neurosci. 34, 629-637, 2011&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22051158\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Sato-Hashimoto M, Saito Y, Ohnishi H, Iwamura H, Kanazawa Y, Kaneko T, Kusakari S, Kotani T, Mori M, Murata Y, Okazawa H, Ware CF, Oldenborg P-A, Nojima Y, Matozaki T.<br><strong>Signal regulatory protein \u03b1 regulates the homeostasis of T lymphocytes in the spleen<\/strong><br>J Immunol 187, 291-297, 2011&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21632712\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Iwamura H, Saito Y, Sato-Hashimoto M, Ohnishi H, Murata Y, Okazawa H, Kanazawa Y, Kaneko T, Kusakari S, Kotani T, Nojima Y, Matozaki T.<br><strong>Essential roles of SIRP\u03b1 in homeostatic regulation of skin dendritic cells<\/strong><br>Immunol Lett 135, 100-107, 2011 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20955735\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n<\/ul>\n\n\n\n<p><a href=\"#top\">\u25b2TOP<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2010<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Kanazawa Y, Sato Y, Supriatna Y, Tezuka H., Kotani T., Murata Y., Okazawa H., Ohnishi H., Kinouchi Y., Nojima Y., Ohteki T., Shimosegawa T., Matozaki T.<br><strong>Role of SIRP\u03b1 in regulation of mucosal immunity in the intestine<\/strong><br>Genes Cells 15, 1189-1200, 2010 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21040253\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Morimoto N, Murata Y, Motegi S, Suzue K, Saito Y, Okazawa H, Ohnishi H, Kotani T, Kusakari S, Ishikawa O, Matozaki T.<br><strong>Requirement of SIRP\u03b1 for protective immunity against Leishmania major<\/strong><br>Biochem Biophys Res Commun 401, 385-389, 2010 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20854790\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Saito Y, Iwamura H, Kaneko T, Ohnishi H, Murata Y, Okazawa H, Kanazawa Y, Sato-Hashimoto M, Kobayashi H, Oldenborg P-A, Naito M, Kaneko Y, Nojima Y, Matozaki T.<br><strong>Regulation by SIRP\u03b1 of dendritic cell homeostasis in lymphoid tissues<\/strong><br>Blood 116, 3517-3525, 2010 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20682853\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Ohnishi H, Murata T, Kusakari S, Hayashi Y, Takao K, Maruyama T, Ago Y, Koda K, Jin F-J, Okawa K, Oldenborg P-A, Okazawa H, Murata Y, Furuya N, Matsuda T, Miyakawa T, Matozaki T.<br><strong>Stress-evoked tyrosine phosphoryaltion of signal regulatory protein \u03b1 regulates behavioral immobility in the forced swim test<\/strong><br>J Neurosci 30, 10472-10483, 2010 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20685990\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Matozaki T, Murata Y, Mori M, Kotani T, Okazawa H, Ohnishi H.<br><strong>Expression, localization, and biological function of the R3 subtype of receptor-type protein tyrosine phosphatases in mammals<\/strong><br>Cell Signal 22, 1811-1817, 2010 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20633639\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Murata Y, Mori M, Kotani T, Supriatna, Y, Okazawa H, Kusakari S, Saito Y, Ohnishi H, Matozaki T.<br><strong>Tyrosine phosphorylation of R3 subtype receptor-type protein tyrosine phosphatases and their complex formations with Grb2 or Fyn<\/strong><br>Genes Cells 15, 513-524, 2010 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20398064\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Mori M, Murata Y, Kotani T, Kusakari S, Ohnishi H, Saito Y, Okazawa H, Ishizuka T, Mori M, Matozaki T.<br><strong>Promotion of cell spreading and migration by vascular endothelial-protein tyrosine phosphatase (VE-PTP) in cooperation with integrins<\/strong><br>J Cell Physiol 224, 195-204, 2010 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20301196\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Kotani T, Murata Y, Ohnishi H, Mori M, Kusakari S, Saito Y, Okazawa H, Bixby JL, Matozaki T.<br><strong>Expression of PTPRO in the interneurons of adult mouse olfactory bulb<\/strong><br>J Comp Neurol 518, 119-136, 2010 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19924828?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&amp;ordinalpos=1\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n<\/ul>\n\n\n\n<p><a href=\"#top\">\u25b2TOP<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2009<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Matozaki T, Murata Y, Saito Y, Okazawa H, Ohnishi H.<br><strong>Protein tyrosine phosphatase SHP-2: A proto-oncogene product that promotes Ras activation<\/strong><br>Cancer Sci. 100, 1786-1793, 2009 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19622105?ordinalpos=2&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Sadakata H, Okazawa H, Sato T, Supriatna Y, Ohnishi H, Kusakari S, Murata Y, Ito T, Nishiyama U, Minegishi T, Harada A, Matozaki T.<br><strong>SAP-1 is a microvillus-specific protein tyrosine phosphatase that modulates intestinal tumorigenesis<\/strong><br>Genes Cells 14, 295-308, 2009 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19170756?ordinalpos=1&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Matozaki T, Murata Y, Okazawa H, Ohnishi H.<br><strong>Functions and molecular mechanisms of the CD47-SIRP\u03b1 signalling pathway<\/strong><br>Trends Cell Biol 19, 72-80, 2009 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19144521?ordinalpos=2&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n<\/ul>\n\n\n\n<p><a href=\"#top\">\u25b2TOP<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2008<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Motegi S, Okazawa H, Murata Y, Kanazawa Y, Saito Y, Kobayashi H, Ohnishi H, Oldenborg P-A, Ishikawa O, Matozaki T.<br><strong>Essential roles of SHPS-1 in induction of contact hypersensitivity of skin<\/strong><br>Immunol Lett 121, 52-60, 2008 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18809435?ordinalpos=1&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Kobayashi M, Ohnishi H, Okazawa H, Murata Y, Hayashi Y, Kobayashi H, Kitamura T, Matozaki T.<br><strong>Expression of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 in pancreatic \u03b2-cells and its role in promotion of insulin secretion and protection against diabetes<\/strong><br>Endocrinology 149, 5662-5669, 2008 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18635660?ordinalpos=2&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Okuzawa C, Kaneko Y, Murata Y, Miyake A, Saito Y, Okajo J, Tomizawa T, Kaneko Y, Okazawa H, Ohnishi H, Matozaki T, Nojima Y.<br><strong>Resistance to collagen-induced arthritis in SHPS-1 mutant mice<\/strong><br>Biochem Biophys Res Commun 371, 561-566, 2008 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18455510?ordinalpos=1&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Kusakari S, Ohnishi H, Jin F-J, Kaneko Y, Murata T, Murata Y, Okazawa H, Matozaki T.<br><strong>Trans-endocytosis of CD47 and SHPS-1 and its role in regulation of the CD47-SHPS-1 system<\/strong><br>J Cell Sci 121, 1213-1223, 2008 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18349073?ordinalpos=1&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Kaneko Y, Kaneko Y, Ohnishi H, Tomizawa T, Okajo J, Saito Y, Okuzawa C, Murata Y, Okazawa H, Nojima Y, Okamoto K, Matozaki T.<br><strong>Impaired proliferation and Th1 differentiation of CD4+ T cells of SHPS-1 mutant mice<\/strong><br>Kitakanto Med J 58, 133-139, 2008<\/li>\n\n\n\n<li>Miyake A, Murata Y, Okazawa H, Ikeda H, Niwayama Y, Ohnishi H, Hirata Y, Matozaki T.<br><strong>Negative regulation by SHPS-1 of Toll-like receptor-dependent proinflammatory cytokine production in macrophages<\/strong><br>Genes Cells 13, 209-219, 2008 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18233962?ordinalpos=1&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Nakaishi A, Hirose M, Yoshimura M, Oneyama C, Saito K, Kuki N, Matsuda M, Honma N, Ohnishi H, Matozaki T, Okada M, Nakagawa A.<strong><br>Structural insight into the specific interaction between murine SHPS-1\/SIRP\u03b1&nbsp;and its ligand CD47<\/strong><br>J Mol Biol 375, 650-660, 2008 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18045614?ordinalpos=10&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n<\/ul>\n\n\n\n<p><a href=\"#top\">\u25b2TOP<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2007<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Tomizawa T, Kaneko Y, Kaneko Y, Saito Y, Ohnishi H, Okajo J, Okuzawa C, Ishikawa-Sekigami T, Murata Y, Okazawa H, Okamoto K, Nojima Y, Matozaki T.<br><strong>Resistance to experimental autoimmune encephalomyelitis and impaired T cell priming by dendritic cells in src homology 2 domain-containing protein tyrosine phosphatase substrate-1 mutant mice<\/strong><br>J Immunol 179, 869-877, 2007 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?Db=pubmed&amp;Cmd=ShowDetailView&amp;TermToSearch=17617577&amp;ordinalpos=1&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Okajo J, Kaneko Y, Murata Y, Tomizawa T, Okuzawa C, Saito Y, Kaneko Y, Ishikawa-Sekigami T, Okazawa H, Ohnishi H, Matozaki T, Nojima Y.<br><strong>Regulation by src homology 2 domain-containing protein tyrosine phosphatase substrate-1 of \u03b1-Galactosylceramide-induced antimetastatic activity and Th1 and Th2 responses of NKT cells<\/strong><br>J Immunol 178, 6164-6172, 2007 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?Db=pubmed&amp;Cmd=ShowDetailView&amp;TermToSearch=17475843&amp;ordinalpos=1&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n<\/ul>\n\n\n\n<p><a href=\"#top\">\u25b2TOP<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2006<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Ishikawa-Sekigami T., Kaneko Y., Okazawa H., Tomizawa T., Okajo J., Saito Y., Okuzawa C., Sugawara-Yokoo M., Nishiyama U., Ohnishi H., Matozaki T., Nojima Y.<br><strong>SHPS-1 promotes the survival of circulating erythrocytes through inhibition of phagocytosis by splenic macrophages<\/strong><br>Blood 107, 341-348, 2006 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=pubmed&amp;cmd=Retrieve&amp;dopt=AbstractPlus&amp;list_uids=16141346&amp;query_hl=1&amp;itool=pubmed_docsum\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Ikeda H., Okazawa H, Ohnishi H., Murata T., Oldenborg P.-A., Matozaki T.<br><strong>Mutational analysis of the mechanism of negative regulation by SRC homology 2 domain-containing protein tyrosine phosphatase substrate-1 of phagocytosis in macrophages<\/strong><br>J. Immunol. 177, 3123-3132, 2006 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=pubmed&amp;cmd=Retrieve&amp;dopt=AbstractPlus&amp;list_uids=16920950&amp;query_hl=1&amp;itool=pubmed_docsum\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Murata T., Ohnishi H., Okazawa H., Murata Y., Kusakari S., Hayashi Y., Miyashita M., Itoh H., Oldenborg P.A., Furuya N., Matozaki T.<br><strong>CD47 promotes neuronal development through Src- and FRG\/Vav2-mediated activation of Rac and Cdc42<\/strong><br>J. Neurosci. 26, 12397-12407, 2006 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=pubmed&amp;cmd=Retrieve&amp;dopt=AbstractPlus&amp;list_uids=17135401&amp;query_hl=1&amp;itool=pubmed_docsum\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Ishikawa-Sekigami T., Kaneko Y., Saito Y., Murata Y., Okazawa H., Ohnishi H., Oldenborg P.A., Nojima Y., Matozaki T.<br><strong>Enhanced phagocytosis of CD47-deficient red blood cells by splenic macrophages requires SHPS-1<\/strong><br>Biochem. Biophys. Res. Commun. 343, 1197-1200, 2006 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=pubmed&amp;cmd=Retrieve&amp;dopt=AbstractPlus&amp;list_uids=16580635&amp;query_hl=1&amp;itool=pubmed_docsum\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Shinohara M., Ohyama N., Murata Y., Okazawa H., Ohnishi H., Ishikawa O., Matozaki T.<br><strong>CD47 regulation of epithelial cell spreading and migration, and its signal transduction<\/strong><br>Cancer Sci. 97, 889-895, 2006 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=pubmed&amp;cmd=Retrieve&amp;dopt=AbstractPlus&amp;list_uids=16776778&amp;query_hl=50&amp;itool=pubmed_docsum\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Nagata A., Ohnishi H., Yoshimura M., Ogawa A., Ujita S., Adachi H., Okada M., Matozaki T., Nakagawa A.<br><strong>Crystallization and preliminary X-ray analysis of rat SHPS-1<\/strong><br>Acta Crystallograph. Sec. F Struct Biol. Cryst. Commun. 62(Pt 3), 189-191, 2006 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=pubmed&amp;cmd=Retrieve&amp;dopt=AbstractPlus&amp;list_uids=16511298&amp;query_hl=1&amp;itool=pubmed_docsum\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n<\/ul>\n\n\n\n<p><a href=\"#top\">\u25b2TOP<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2005<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Ohnishi H., Kaneko Y., Okazawa H., Miyashita M., Sato R., Hayashi A., Tada K., Nagata S., Takahashi M., Matozaki T.<br><strong>Differential localization of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 and CD47 and its molecular mechanisms in cultured hippocampal neurons<\/strong><br>J. Neurosci. 25, 2702-2711, 2005 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=15758180\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Okazawa H., Motegi S., Ohyama N., Ohnishi H., Tomizawa T., Kaneko Y., Oldenborg P.A., Ishikawa O., Matozaki T.<br><strong>Negative regulation of phagocytosis in macrophages by the CD47\u2013SHPS-1 system<\/strong><br>J. Immunol. 174, 2004-2011, 2005 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=15699129\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n<\/ul>\n\n\n\n<p><a href=\"#top\">\u25b2TOP<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2004<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Ohnishi H., Kobayashi H., Okazawa H., Ohe Y., Tomizawa K., Sato R., Matozaki T.<br><strong>Ectodomain shedding of SHPS-1 and its role in regulation of cell migration.<\/strong><br>J. Biol. Chem. 279, 27878-27887, 2004 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=15123722\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Hayashi A., Ohnishi H., Okazawa H., Nakazawa S., Ikeda H., Motegi S., Aoki N., Kimura S., Mikuni M., Matozaki T.<br><strong>Positive regulation of phagocytosis by SIRP\u03b2 and its signaling mechanism in macrophages.<\/strong><br>J. Biol. Chem. 279, 29450-29460, 2004 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=15123631\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Miyashita M., Ohnishi H., Okazawa H., Tomonaga H., Hayashi A., Fujimoto T.-T., Furuya N., Matozaki T.<br><strong>Promotion of Neurite and Filopodium Formation by CD47: Roles of integrins, Rac, and Cdc42.<\/strong><br>Mol. Biol. Cell 15, 3950-3963, 2004 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=15215311\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Murai-Takebe R., Noguchi T., Ogura T., Mikami T., Yanagi K., Inagaki K., Ohnishi H., Matozaki T., Kasuga M.<br><strong>Ubiquitination-mediated regulation of biosynthesis of the adhesion receptor SHPS-1 in response to endoplasmic reticulum stress.<\/strong><br>J. Biol. Chem. 279, 11616-11625, 2004 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=14701835\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Koga T., Inui M., Inoue K., Kim S., Suematsu A., Kobayashi E., Iwata T., Ohnishi H., Matozaki T., Kodama T., Taniguchi T., Takayanagi H., Takai T.<br><strong>Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis.<\/strong><br>Nature 424, 758-763, 2004 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=15085135\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n<\/ul>\n\n\n\n<p><a href=\"#top\">\u25b2TOP<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2003<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Motegi S., Okazawa H., Ohnishi H., Sato R., Kaneko Y., Kobayashi H., Tomizawa K., Ito T., Honma N., Buhring H.J., Ishikawa O., Matozaki T.<br><strong>Role of the CD47-SHPS-1 system in regulation of cell migration.<\/strong><br>EMBO J. 22, 2634-2644, 2003 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=12773380&amp;dopt=Abstract\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Ito T., Okazawa H., Maruyama K., Tomizawa K., Motegi S., Ohnishi H., Kuwano H., Kosugi A., Matozaki T.<br><strong>Interaction of SAP-1, a transmembrane-type protein tyrosine phosphatase, with the tyrosine kinase Lck: Roles in regulation of T cell function.<\/strong><br>J. Biol. Chem. 278, 34854-34863, 2003 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=12837766&amp;dopt=Abstract\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Ohe Y., Ohnishi H., Okazawa H., Tomizawa K., Kobayashi H., Okawa K., Matozaki T.<br><strong>Characterization of nucleotide pyrophosphatase-5 as an oligomannosidic glycoprotein in rat brain.<\/strong><br>Biochem. Biophys. Res. Commun. 308, 719-725, 2003 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=12927778&amp;dopt=Abstract\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Sato R., Ohnishi H., Kobayashi H., Kiuchi D., Hayashi A., Sakazume-Kaneko Y., Honma N., Okazawa H., Hirata Y., Matozaki T.<br><strong>Regulation of multiple functions of SHPS-1, a transmembrane glycoprotein, by its cytoplasmic region.<\/strong><br>Biochem. Biophys. Res. Commun. 309, 584-590, 2003 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=12927778&amp;dopt=Abstract\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n<\/ul>\n\n\n\n<p><a href=\"#top\">\u25b2TOP<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2002<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Takahashi M. and Ohnishi H.<br><strong>Negative regulation of exocytosis at the nerve terminal.<\/strong><br>Mol. Psychiatry 7(6), 536-537, 2002&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12140773\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Amino S., Itakura M., Ohnishi H., Tsujimura J., Koizumi S., Takei N., Takahashi M.<br><strong>Nerve growth factor enhances neurotransmitter release from PC12 cells by increasing Ca<sup>2+<\/sup>-responsible secretory vesicles through the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase.<\/strong><br>J. Biochem. (Tokyo) 131, 887-894, 2002&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed?term=Hiroshi%20Ohnishi%20Shinya%20Amino\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n<\/ul>\n\n\n\n<p><a href=\"#top\">\u25b2TOP<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2001<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Ohnishi H., Yamamori S., Ono K., Aoyagi K., Kondo S., Takahashi M.<br><strong>A src family tyrosine kinase inhibits neurotransmitter release from neuronal cells.<\/strong><br>Proc. Natl. Acad. Sci. U.S.A. 98, 10930-10935, 2001&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11535829\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Yamasaki S., Nishida K., Hibi M., Sakuma M., Shiina R., Takeuchi A., Ohnishi H., Hirano T., Saito T.<br><strong>Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules.<\/strong><br>J. Biol. Chem. 276, 45175-45183, 2001&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed?term=Docking%20protein%20Gab2%20is%20phosphorylated%20by%20ZAP-70%20and%20negatively%20regulates%20T%20cell%20receptor%20signaling%20by%20recruitment%20of%20inhibitory%20molecules\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n<\/ul>\n\n\n\n<p><a href=\"#top\">\u25b2TOP<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2000<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Araki T, Yamada M, Ohnishi H, Sano S, Uetsuki T, Hatanaka H.<br><strong>Shp-2 specifically regulated several tyrosine-phosphorylated proteins in brain-derived neurotrophic factor signaling in cultured cerebral cortical neurons.<\/strong><br>J Neurochem 74(2): 659-668, 2000&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10646517\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Araki T, Yamada M, Ohnishi H, Sano S, Hatanaka H.<br><strong>BIT\/SHPS-1 enhances brain-derived neurotrophic factor-promoted neuronal survival in cultured cerebral cortical neurons.<br><\/strong>J Neurochem&nbsp;75(4): 1502-1510, 2000&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10987830\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n<\/ul>\n\n\n\n<p><a href=\"#top\">\u25b2TOP<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">1999<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Sano S, Ohnishi H, Kubota M.<br><strong>Gene structure of mouse BIT\/SHPS-1.<\/strong><br><em>Biochem J<\/em>&nbsp;344(Pt3): 667-675, 1999&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10585853\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Yamada M, Ohnishi H, Sano S, Nakatani A, Ikeuchi T, Hatanaka H.<br><strong>Brain-derived neurotrophic factor stimulates interaction of Shp2 with PI3-K and Grb2 in cultured cerebral cortical neurons.<\/strong><br><em>J Neurochem <\/em>73(1): 41-49, 1999&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10386953\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Ohnishi H, Yamada M, Kubota M, Hatanaka H, Sano S.<br><strong>Tyrosine phosphorylation and association of BIT with SHP-2 induced by neurotrophins.<\/strong><br><em>J Neurochem <\/em>72(4): 1402-1408, 1999&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10098842\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n<\/ul>\n\n\n\n<p><a href=\"#top\">\u25b2TOP<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">1998<\/h4>\n\n\n\n<p><a href=\"#top\">\u25b2TOP<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">1997<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Sano S., Ohnishi H., Omori A., Hasegawa J., Kubota M.<br><strong>BIT, an immune antigen receptor-like molecule in the brain.&nbsp;<br><\/strong><em>FEBS Lett<\/em>&nbsp;411(2-3): 327-334, 1997&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9271230\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Yamada M., Ohnishi H., Sano S., Nakatani A., Ikeuchi T., Hatanaka H.&nbsp;<br><strong>Insulin receptor substrate (IRS)-1 and IRS-2 are tyrosine-phosphorylated and associated with phosphatidylinositol 3-kinase in response to brain-derived neurotrophic factor in cultured cerebral cortical neurons.<\/strong><br><em>J Biol Chem<\/em>&nbsp;272(48): 30334-30339, 1997&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9374521\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n\n\n\n<li>Ohnishi H., Kubota M., Sano S.<br><strong>BIT (Bit) maps to mouse chromosome 2.<\/strong><br><em>G<\/em><em>enomics<\/em> 1997; 40(3): 504-506&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9073522\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n<\/ul>\n\n\n\n<p><a href=\"#top\">\u25b2TOP<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">1996<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Ohnishi H., Sato K., Ohtake A., Kubota M., Sano S.<br><strong>Activation of protein tyrosine phosphatase SH-PTP2 by a tyrosine-based activation motif of a novel brain molecule.<\/strong><br><em>J Biol Chem<\/em>&nbsp;271(41): 25569-25574, 1996&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8810330\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><br><\/li>\n<\/ul>\n\n\n\n<p><a href=\"#top\">\u25b2TOP<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">1995<\/h4>\n\n\n\n<p><a href=\"#top\">\u25b2TOP<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">1994<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Ohnishi H., Matsumoto H., Sakai H., Ohta T.<br><strong>Functional roles of Trp337 and Glu632 in <em>Clostridium<\/em> glucoamylase, as determined by chemical modification, mutagenesis, and the stopped-flow method.<\/strong><br><em>J Biol Chem<\/em>&nbsp;269(5): 3503-3510, 1994&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7906268\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><br><\/li>\n<\/ul>\n\n\n\n<p><a href=\"#top\">\u25b2TOP<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">1993<\/h4>\n\n\n\n<p><a href=\"#top\">\u25b2TOP<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">1992<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Ohnishi H., Kitamura H., Minowa T., Sakai H., Ohta T.<br><strong>Molecular cloning of a glucoamylase gene from a thermophilic <em>Clostridium<\/em> and kinetics of the cloned enzyme.<\/strong><br><em>Eur J Biochem<\/em>&nbsp;207(2): 413-418, 1992&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/1633799\" target=\"_blank\" rel=\"noreferrer noopener\">[PubMed]<\/a><\/li>\n<\/ul>\n\n\n\n<p><a href=\"#top\">\u25b2TOP<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">1991<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Ohnishi H., Sakai H., Ohta T.<br><strong>Purification and some properties of glucoamylase from <em>Clostridium sp.<\/em> G0005.<\/strong><br><em>Agric Biol Chem<\/em>&nbsp;55: 1901-1902, 1991&nbsp;<a href=\"https:\/\/www.jstage.jst.go.jp\/article\/bbb1961\/55\/7\/55_7_1901\/_article\" target=\"_blank\" rel=\"noreferrer noopener\">[J-STAGE]<\/a><\/li>\n<\/ul>\n\n\n\n<p><a href=\"#top\">\u25b2TOP<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>2025 \u25b2TOP 2023 \u25b2TOP 2022 \u25b2TOP 2021 \u25b2TOP 2020 \u25b2TOP 2019 \u25b2TOP 2018 \u25b2TOP 2017 \u25b2TOP 2016 \u25b2TOP 2015 \u25b2TOP 2014 \u25b2TOP  [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":30,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-2.php","meta":{"footnotes":""},"class_list":["post-38","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/biosignal.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/38","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biosignal.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/biosignal.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/biosignal.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/biosignal.dept.med.gunma-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=38"}],"version-history":[{"count":5,"href":"https:\/\/biosignal.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/38\/revisions"}],"predecessor-version":[{"id":925,"href":"https:\/\/biosignal.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/38\/revisions\/925"}],"up":[{"embeddable":true,"href":"https:\/\/biosignal.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/30"}],"wp:attachment":[{"href":"https:\/\/biosignal.dept.med.gunma-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=38"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}