{"id":86,"date":"2024-02-15T16:28:50","date_gmt":"2024-02-15T07:28:50","guid":{"rendered":"https:\/\/ohnishi.mc-tsukuba.com\/?page_id=86"},"modified":"2024-02-28T12:09:11","modified_gmt":"2024-02-28T03:09:11","slug":"r-01","status":"publish","type":"page","link":"https:\/\/biosignal.dept.med.gunma-u.ac.jp\/?page_id=86","title":{"rendered":"\u65b0\u898f\u7d30\u80de\u9593\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30b7\u30b9\u30c6\u30e0CD47-SHPS-1\u7cfb\u306e\u6a5f\u80fd"},"content":{"rendered":"\n

(\u7d30\u80de\u5de5\u5b66 vol.23, No.5, 2004)<\/strong><\/p>\n

Physiological Functions of a Novel Cell-cell Signaling System, the CD47-SHPS-1 System.

\u5927\u897f\u3000\u6d69\u53f2\u3001\u5ca1\u6fa4\u3000\u79c0\u6a39\u3001\u7684\u5d0e\u3000\u5c1a<\/strong>
Hiroshi Ohnishi, Hideki Okazawa, Takashi Matozaki<\/strong><\/p>\n

\u8981\u65e8<\/h4>\n

\u819c\u86cb\u767d\u8ceaSHPS-1\u306f\u7d30\u80de\u5185\u9818\u57df\u306e\u30c1\u30ed\u30b7\u30f3\u30ea\u30f3\u9178\u5316\u4f9d\u5b58\u7684\u306b\u30c1\u30ed\u30b7\u30f3\u30db\u30b9\u30d5\u30a1\u30bf\u30fc\u30bcSHP-2\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u7d30\u80de\u5185\u30c1\u30ed\u30b7\u30f3\u30ea\u30f3\u9178\u5316\u30b7\u30b0\u30ca\u30eb\u3092\u5236\u5fa1\u3059\u308b\u3002\u4e00\u65b9\u3067SHPS-1\u306e\u7d30\u80de\u5916\u9818\u57df\u306f\uff15\u56de\u819c\u8cab\u901a \u578b\u86cb\u767d\u8ceaCD47\u306e\u7d30\u80de\u5916\u9818\u57df\u3068\u30c8\u30e9\u30f3\u30b9\u306b\u76f8\u4e92\u4f5c\u7528\u3057\u3001\u7d30\u80de\u9593\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30b7\u30b9\u30c6\u30e0CD47-SHPS-1\u7cfb\u3092\u69cb\u6210\u3059\u308b\u3002\u6700\u8fd1\u306e\u7814\u7a76\u304b\u3089CD47-SHPS-1\u7cfb\u304c\u591a\u69d8\u306a\u7d30\u80de\u6a5f\u80fd\u3092\u4e3b\u306b\u8ca0\u306b\u5236\u5fa1\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u305f\u3002<\/p>\n

Key words: \u7d30\u80de\u9593\u76f8\u4e92\u4f5c\u7528\u3001\u30a4\u30e0\u30ce\u30b0\u30ed\u30d6\u30ea\u30f3\u30b9\u30fc\u30d1\u30fc\u30d5\u30a1\u30df\u30ea\u30fc\u3001SHPS-1\u3001CD47\u3001\u7d30\u80de\u904b\u52d5\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3001\u795e\u7d4c\u7d30\u80de<\/p>\n

\u306f\u3058\u3081\u306b<\/h4>\n

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\"\"<\/p>\n

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\u25b2TOP<\/a><\/p>\n

II. CD47-SHPS-1\u7cfb\u306e\u767a\u898b<\/h5>\n

SHPS-1\u306f\u3001\u7d44\u7e54\u666e\u904d\u7684\u306b\u767a\u73fe\u3057\u3066\u3044\u308b\u304c\u795e\u7d4c\u7cfb\u3068\u514d\u75ab\u7cfb\u3067\u7279\u306b\u5f37\u304f\u767a\u73fe\u3059\u308b\u3002\u7c73\u56fd\u30d4\u30c3\u30c4\u30d0\u30fc\u30b0\u5927\u5b66\u306eLagenaur \u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u7a81\u8d77\u4f38\u9577\u4f5c\u7528\u306e\u3042\u308b\u5206\u5b50\u91cf 84 kDa \u306e\u819c\u86cb\u767d\u8cea\u3092\u7cbe\u88fd\u3057p84\u3068\u547d\u540d\u3057\u305f\uff16\uff09\u3002\u307e\u305f\u3001\u4e09\u83f1\u5316\u5b66\u751f\u547d\u79d1\u5b66\u7814\u7a76\u6240\u306eSano\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u3084\u306f\u308a\u795e\u7d4c\u306b\u5f37\u304f\u767a\u73fe\u3059\u308b\u9ad8\u5ea6\u306b\u7cd6\u4ed8\u52a0\u3055\u308c\u305f\u819c\u86cb\u767d\u8cea \u3068\u3057\u3066BIT\u3092\u898b\u3044\u51fa\u3057\u3066\u3044\u305f\uff15\uff09\u3002\u305d\u306e\u5f8c\u3001p84\u3042\u308b\u3044\u306fBIT\u306e\u907a\u4f1d\u5b50\u304c\u30af\u30ed\u30fc\u30cb\u30f3\u30b0\u3055\u308c\u3001\u3053\u308c\u3089\u306e\u5206\u5b50\u304cSHPS-1\u3068\u540c\u4e00\u5206\u5b50\u3067\u3042\u308b\u3053\u3068\u304c\u5831\u544a\u3055 \u308c\u305f\uff17\uff09\uff18\uff09\u3002\u3055\u3089\u306bLagenaur\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001p84\u306e\u7d30\u80de\u5916\u9818\u57df\u306e\u7d50\u5408\u5206\u5b50\u3092\u540c\u5b9a\u3057\u3001\u3053\u308c\u304c\u3084\u306f\u308a\u30ec\u30bb\u30d7\u30bf\u30fc\u578b\u306e\u819c\u86cb\u767d\u8cea\u3067\u3042\u308bCD47\u3067\u3042\u308b \u3053\u3068\u3092\u898b\u3044\u51fa\u3057\u305f\uff19\uff09\u3002\u3059\u306a\u308f\u3061\u3001SHPS-1\u3068CD47\u306f\u5404\u3005\u306e\u7d30\u80de\u5916\u9818\u57df\u3092\u4ecb\u3057\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u5168\u304f\u65b0\u305f\u306a\u7d30\u80de\u9593\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7cfb\u3092\u69cb\u6210\u3059\u308b\u3053 \u3068\u304c\u660e\u3089\u304b\u3068\u306a\u3063\u305f\u306e\u3067\u3042\u308b\uff08\u56f3\uff12\uff09\u3002CD47\u306f\u7d44\u7e54\u666e\u904d\u7684\u306b\u767a\u73fe\u3059\u308b\uff15\u56de\u7d30\u80de\u819c\u8cab\u901a \u578b\u306e\u86cb\u767d\u8cea\u3067\u3042\u308a\u3001\u6b74\u53f2\u7684\u306b\u306f\u7d30\u80de\u63a5\u7740\u5206\u5b50\u3067\u3042\u308b\u30a4\u30f3\u30c6\u30b0\u30ea\u30f3\u306b\u95a2\u9023\u3059\u308b\u5206\u5b50\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u305f\u3053\u3068\u304b\u3089\u5225 \u540dIAP\uff08Integrin-Associated Protein\uff09\u3068\u3082\u547c\u3070\u308c\u3066\u3044\u308b\uff11\uff10\uff09\u3002\u305d\u306e\u7d30\u80de\u5916\u9818\u57df\u306b\u306f\uff11\u500b\u306e\u514d\u75ab\u30b0\u30ed\u30d6\u30ea\u30f3\u69d8\u69cb\u9020\u3092\u3082\u3061\u3001\u3053\u308c\u304cSHPS-1\u306eN\u672b\u7aef\u5074\u306e\u514d\u75ab\u30b0\u30ed\u30d6\u30ea\u30f3\u69d8\u69cb\u9020\u306b \u7d50\u5408\u3059\u308b\u3002<\/p>\n

\"\"<\/p>\n

\u56f3\uff12\uff0eCD47\u3068SHPS-1\u306b\u3088\u308b\u7d30\u80de\u9593\u76f8\u4e92\u4f5c\u7528 \uff21\uff1a\u7d30\u80de\u8868\u9762\u306eSHPS-1\uff08\u7d30\u80de\uff22\uff09\u306f\u3001\u96a3\u63a5\u3059\u308b\u7d30\u80de\uff08\u7d30\u80de\uff21\uff09\u4e0a\u306eCD47\u3068\u30c8\u30e9\u30f3\u30b9\u306b\u76f8\u4e92\u4f5c\u7528\u3057\u3001\u53cc\u65b9\u5411\u6027\u306b\u30b7\u30b0\u30ca\u30eb\u3092\u4f1d\u3048\u308b\u7d30\u80de\u9593\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7cfb \uff08CD47-SHPS-1\u7cfb\uff09\u3092\u5f62\u6210\u3059\u308b\u3002\uff22\uff1a\u30de\u30a6\u30b9CD47\u304a\u3088\u3073\u30de\u30a6\u30b9SHPS-1\u3092\u5b89\u5b9a\u306b\u767a\u73fe\u3059\u308b\u682a\u7d30\u80de\uff08CHO-Ras\u7d30\u80de\uff09\u3092\u6df7\u5408\u3059\u308b\u3068\u7d30\u80de\u306e \u51dd\u96c6\u304c\u8a8d\u3081\u3089\u308c\u3001CD47\u3068SHPS-1\u304c\u30c8\u30e9\u30f3\u30b9\u306b\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u6d3b\u6027\u3092\u6301\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u308b\uff08\u5de6\u56f3\uff09\u3002\u307e\u305f\u30d2\u30c8CD47\u3068\u30de\u30a6\u30b9SHPS-1\u3092\u767a\u73fe\u3055 \u305b\u305f\u7d30\u80de\u9593\u3067\u306f\u3053\u306e\u69d8\u306a\u7d30\u80de\u51dd\u96c6\u584a\u306e\u5f62\u6210\u306f\u8a8d\u3081\u3089\u308c\u305a\u3001CD47\u3068SHPS-1\u306e\u76f8\u4e92\u4f5c\u7528\u304c\u52d5\u7269\u7a2e\u306b\u7279\u7570\u7684\u3067\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u308b\uff08\u53f3\u56f3\uff09\u3002 \u3000<\/span><\/p>\n

\u25b2TOP<\/a><\/p>\n

III. \u7d30\u80de\u904b\u52d5\u3068CD47-SHPS-1\u7cfb<\/h5>\n

\u79c1\u5171\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001SHPS-1\u306e\u751f\u7406\u6a5f\u80fd\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u306bSHPS-1\u306e\u907a\u4f1d\u5b50\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u3092\u4f5c\u6210\u3057 \u305f\u3002\u3053\u306e\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u7531\u6765\u7dda\u7dad\u82bd\u7d30\u80de\u3067\u306f\u4f4e\u5206\u5b50\u91cf G\u86cb\u767d\u8ceaRho\u306e\u6d3b\u6027\u5316\u304c\u969c\u5bb3\u3055\u308c\u3066\u3044\u308b\u3068\u5171\u306b\u7d30\u80de\u904a\u8d70\u80fd\u306e\u4f4e\u4e0b\u304c\u8a8d\u3081\u3089\u308c\u308b\uff11\uff11\uff09\u3002\u3053\u306e\u69d8\u306a\u7d30\u80de\u904a\u8d70\u80fd\u306e\u5909\u5316\u306bSHPS-1\u3068CD47\u306e\u76f8\u4e92\u4f5c\u7528\u304c\u3069\u306e \u3088\u3046\u306b\u95a2\u308f\u308b\u304b\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u3001\u79c1\u5171\u306f\u3055\u3089\u306b\u3001\u5185\u5728\u6027\u306bSHPS-1\u3092\u767a\u73fe\u3059\u308b\u30d2\u30c8\u30e1\u30e9\u30ce\u30fc\u30de\u7d30\u80de\u3092\u7528\u3044\u3001CD47-SHPS-1\u7cfb\u306b\u3088\u308b\u7d30\u80de\u904b\u52d5\u306e \u5236\u5fa1\u306b\u3064\u3044\u3066\u691c\u8a0e\u3092\u884c\u3063\u305f\u3002\u4eba\u5de5\u7684\u306a\u30ea\u30ac\u30f3\u30c9\uff08\u30ea\u30b3\u30f3\u30d3\u30ca\u30f3\u30c8CD47\u3042\u308b\u3044\u306fSHPS-1\u7279\u7570\u7684\u6297\u4f53\uff09\u306b\u3088\u308a\u30e1\u30e9\u30ce\u30fc\u30de\u7d30\u80de\u8868\u9762 SHPS-1\u3092\u67b6\u6a4b\u3057\u305f\u3068\u3053\u308d\u3001\u7d30\u80de\u904b\u52d5\u306e\u6709\u610f\u306a\u6291\u5236\u304c\u898b\u3089\u308c\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u305f\uff11\uff12\uff09\uff08\u56f3\uff13A-C\uff09\u3002\u3055\u3089\u306b\u3053\u306e\u6291\u5236\u4f5c\u7528\u306b\u306fSHPS-1\u306e\u8131\u30ea\u30f3\u9178\u5316\u3068 Rho\u306e\u6d3b\u6027\u5316\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\uff11\uff12\uff09\u3002\u4e00\u9023\u306e\u89e3\u6790\u7d50\u679c \u304b\u3089\u3001\u79c1\u5171\u306f\u3001SHPS-1\u306e\u30c1\u30ed\u30b7\u30f3\u30ea\u30f3\u9178\u5316\u306f\u4e0b\u6d41\u30b7\u30b0\u30ca\u30eb\u5206\u5b50SHP-2\u306e\u6d3b\u6027\u5316\u3092\u4ecb\u3057\u3066Rho\u30b7\u30b0\u30ca\u30eb\u3092\u6291\u5236\u3057\u3001\u7d50\u679c \u3068\u3057\u3066\u7d30\u80de\u904b\u52d5\u3092\u4fc3\u9032\u7684\u306b\u5236\u5fa1\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3066\u3044\u308b\uff08\u56f3\uff13D\uff09\u3002\u30ea\u30ac\u30f3\u30c9\u3067\u3042\u308bCD47\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306f\u7d30\u80de\u8868\u9762 \u306b\u304a\u3044\u3066SHPS-1\u306e\u67b6\u6a4b\u3092\u8a98\u5c0e\u3057\u3001\u3053\u308c\u306b\u3088\u3063\u3066SHPS-1\u306e\u8131\u30ea\u30f3\u9178\u5316\u304c\u4fc3\u9032\u3057\u3001SHP-2\u3092\u4ecb\u3057\u305fRho\u306e\u6291\u5236\u304c\u89e3\u9664\u3055\u308c\u308b\u3053\u3068\u3067\u7d30\u80de\u904b\u52d5\u304c\u8ca0\u306b \u5236\u5fa1\u3055\u308c\u308b\u3053\u3068\u304c\u8003\u3048\u3089\u308c\u308b\u3002\u3053\u306e\u69d8\u306aCD47-SHPS-1\u7cfb\u306e\u50cd\u304d\u306b\u3088\u308a\u3001 SHPS-1\u3092\u767a\u73fe\u3059\u308b\u7d30\u80de\u304cCD47\u3092\u767a\u73fe\u3057\u3066\u3044\u308b\u96a3\u63a5\u7d30\u80de\u3068\u63a5\u89e6\u3057\u305f\u5834\u5408\u3001\u305d\u306e\u904b\u52d5\u304c\u52b9\u679c \u7684\u306b\u6291\u5236\u3055\u308c\u308b\u3053\u3068\u304c\u4e88\u6e2c\u3055\u308c\u3001\u6b63\u5e38\u7d30\u80de\u3067\u898b\u3089\u308c\u308b\u63a5\u89e6\u963b\u5bb3\u73fe\u8c61\u306b\u3082CD47-SHPS-1\u7cfb\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u8003\u3048\u3089\u308c\u308b\u3002<\/p>\n

\"\"<\/p>\n

\u56f3\uff13\uff0eCD47-SHPS-1\u7cfb\u306b\u3088\u308b\u30e1\u30e9\u30ce\u30fc\u30de\u7d30\u80de\u306e\u904b\u52d5\u6291\u5236 \uff21\uff1a\u5fae\u5c0f\u5b54\u3092\u6301\u3064\u30d5\u30a3\u30eb\u30bf\u30fc\u3067\u5206\u3051\u3089\u308c\u305f\u30c1\u30e3\u30f3\u30d0\u30fc\u306e\u4e0a\u90e8\u306b\u7d30\u80de\u3092\u52a0\u3048\u3001\u4e00\u5b9a\u6642\u9593\u306e\u3046\u3061\u306b\u30c1\u30e3\u30f3\u30d0\u30fc\u4e0b\u90e8\u3078\u79fb\u52d5\u3057\u305f\u7d30\u80de\u3092\u30ab\u30a6\u30f3\u30c8\u3057\u3066\u3001\u7d30\u80de\u904b\u52d5\u3092\u8a55\u4fa1\u3057 \u305f\u3002\u30c1\u30e3\u30f3\u30d0\u30fc\u4e0a\u90e8\u306b\u52a0\u3048\u308b\u7d30\u80de\u3092\u3001\u3042\u3089\u304b\u3058\u3081SHPS-1\u306e\u4eba\u5de5\u7684\u306a\u30ea\u30ac\u30f3\u30c9\uff08SHPS-1\u7279\u7570\u7684\u6297\u4f53\u3001\u3042\u308b\u3044\u306f\u30d2\u30c8\u30a4\u30e0\u30ce\u30b0\u30ed\u30d6\u30ea\u30f3\u9818\u57df\u3068CD47\u306e \u7d30\u80de\u5916\u9818\u57df\u3092\u878d\u5408\u3055\u305b\u305f\u53ef\u6eb6\u6027\u30ea\u30b3\u30f3\u30d3\u30ca\u30f3\u30c8\u86cb\u767d\u8ceaCD47-Fc\uff09\u3067\u51e6\u7406\u3057\u3001\u7d30\u80de\u8868\u9762 SHPS-1\u3092\u67b6\u6a4b\u3057\u3066\u3001\u7d30\u80de\u904b\u52d5\u3078\u306e\u5f71\u97ff\u3092\u691c\u8a0e\u3057\u305f\u3002 \uff22\uff1a\u306a\u306b\u3082\u52a0\u3048\u306a\u3044\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306b\u6bd4\u3079\u3001SHPS-1\u7279\u7570\u7684\u6297\u4f53\uff08SE12C3\uff09\u3084CD47-Fc\u3067\u51e6\u7406\u3057\u305f\u7d30\u80de\u306f\u6709\u610f\u306b\u7d30\u80de\u904b\u52d5\u304c\u6291\u5236\u3055\u308c\u305f\u3002\u6b63\u5e38\u30de\u30a6 \u30b9IgG\u306b\u3088\u308b\u51e6\u7406\u3067\u306f\u7d30\u80de\u904b\u52d5\u306f\u5f71\u97ff\u3092\u53d7\u3051\u306a\u304b\u3063\u305f\u3002 \uff23\uff1a\u30b3\u30f3\u30d5\u30eb\u30a8\u30f3\u30c8\u72b6\u614b\u306b\u3042\u308b\u30e1\u30e9\u30ce\u30fc\u30de\u7d30\u80de\u306e\u57f9\u990a\u76bf\u3092\u30d7\u30e9\u30b9\u30c1\u30c3\u30af\u30d4\u30da\u30c3\u30c8\u3067\u5f15\u3063\u63bb\u3044\u3066\u3001\u7d30\u80de\u304c\u63bb\u304d\u53d6\u3089\u308c\u305f\u50b7\u3092\u4f5c\u308b\u3002\uff12\uff14\u6642\u9593\u5f8c\u3001\u7d30\u80de\u306e\u79fb\u52d5\u306b\u3088\u308a\u3053 \u306e\u50b7\u304c\u57cb\u3081\u3089\u308c\u3066\u3044\u304f\u69d8\u5b50\u3092\u89b3\u5bdf\u3057\u7d30\u80de\u904b\u52d5\u3092\u8a55\u4fa1\u3057\u305f\u3002\u3053\u306e\u30a2\u30c3\u30bb\u30a4\u65b9\u6cd5\u3067\u3082\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\uff08\u4e0a\u56f3\uff09\u306b\u6bd4\u3079\u3001SHPS-1\u7279\u7570\u7684\u6297\u4f53\uff08SE12C3\uff09\uff08\u4e2d \u56f3\uff09\u3084CD47-Fc\uff08\u4e0b\u56f3\uff09\u306e\u5b58\u5728\u4e0b\u3001\u6709\u610f\u306a\u7d30\u80de\u904b\u52d5\u306e\u6291\u5236\u304c\u8a8d\u3081\u3089\u308c\u305f\u3002 \uff24\uff1aCD47-SHPS-1\u7cfb\u306b\u3088\u308b\u7d30\u80de\u904b\u52d5\u5236\u5fa1\u306e\u30e2\u30c7\u30eb\u3002\u79fb\u52d5\u4e2d\u306e\u7d30\u80de\u304c\u96a3\u63a5\u3059\u308b\u7d30\u80de\u3068\u63a5\u89e6\u3057\u305f\u5834\u5408\u3001\u7d30\u80de\u8868\u9762 \u306eSHPS-1\u304c\u96a3\u63a5\u7d30\u80de\u4e0a\u306eCD47\u3068\u51fa\u4f1a\u3046\u3053\u3068\u3067CD47-SHPS-1\u7cfb\u304c\u4f5c\u52d5\u3057\u3001\u7d30\u80de\u904b\u52d5\u304c\u7279\u7570\u7684\u306b\u6291\u5236\u3055\u308c\u308b\u3002\u6b63\u5e38\u7d30\u80de\u306b\u304a\u3051\u308b\u63a5\u89e6\u963b\u5bb3\u73fe\u8c61\u306b \u3082\u3053\u306e\u3088\u3046\u306aCD47-SHPS-1\u7cfb\u304c\u95a2\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u8003\u3048\u3089\u308c\u308b\u3002 \u3000<\/span><\/p>\n

\u25b2TOP<\/a><\/p>\n

IV. \u514d\u75ab\u7cfb\u306b\u304a\u3051\u308bCD47-SHPS-1\u7cfb<\/h5>\n

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\u25b2TOP<\/a><\/p>\n

\u304a\u308f\u308a\u306b<\/h4>\n

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\u6587\u732e<\/h4>\n
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    \u25b2TOP<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

    (\u7d30\u80de\u5de5\u5b66 vol.23, No.5, 2004) Physiological Functions of a Novel Cell-cell Signaling System, the CD47-SHPS-1 Syste […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-86","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/biosignal.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/86","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biosignal.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/biosignal.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/biosignal.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/biosignal.dept.med.gunma-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=86"}],"version-history":[{"count":1,"href":"https:\/\/biosignal.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/86\/revisions"}],"predecessor-version":[{"id":296,"href":"https:\/\/biosignal.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/86\/revisions\/296"}],"wp:attachment":[{"href":"https:\/\/biosignal.dept.med.gunma-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=86"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}